Bridging structure and function: A model of sequence learning and prediction in primary visual cortex.

Bridging structure and function: A model of sequence learning and prediction in primary visual cortex.

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Recent experiments have demonstrated that visual cortex engages in spatio-temporal sequence learning and prediction.The cellular basis of this learning remains michael harris sunglasses unclear, however.Here we present a spiking neural network model that explains a recent study on sequence learning in the primary visual cortex of rats.The model posits that the sequence learning and prediction abilities of cortical circuits result from the interaction of spike-timing dependent plasticity (STDP) and homeostatic plasticity mechanisms.It also reproduces changes in stimulus-evoked multi-unit activity during learning.

Furthermore, it makes precise predictions regarding how training shapes network connectivity to 15-eg2373cl establish its prediction ability.Finally, it predicts that the adapted connectivity gives rise to systematic changes in spontaneous network activity.Taken together, our model establishes a new conceptual bridge between the structure and function of cortical circuits in the context of sequence learning and prediction.